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In particular, we focused attention on the 48 commonly upregulated genes in cells grown in 3D conditions compared to their 2D counterpart, and based on their known function in the literature, we selected three genes, Ggt1, Sepw1, and Muc1, which together to GPX4 may contribute to give rise to an aggressive and drug-resistant phenotype (Fig
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Though we did not assess estrogen related receptors (ERRs), BPA could also be mediating non-genomic effects by binding to ERR 66 which can also trigger MAPK pathways 28