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Bull Exp Biol Med 2012;153:2558

Do not take two doses within 8 hours

Regarding clinical outcomes, there is evidence, derived from observational and case-control studies, suggesting that in patients with T2DM and advanced fibrosis or cirrhosis associated with MASLD, metformin may improve transplant-free survival without affecting the risk of hepatic decompensation, in addition to reducing the risk of hepatocellular carcinoma and extrahepatic neoplasms

Thanks to the perseverence of researchers like Eng, we got one of the most exciting drugs in modern history