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with direct glucuronidation (~55%) and sulfation (~40%) (Mitchell et al., N -acetyl p -benzoquinone imine (NAPQI), a highly reactive electrophile, which is known to covalently bind to nucleophilic centers, including cysteine thiols in liver proteins (see Figure 1) (Jollow et al., S -transferase (GST) isozymes (Figure 1) (Mitchell et al., Figure 1 GSTs represent major detoxification enzymes with a protein size of ~25 kDa (Eaton and Bammler, 2000) and heavy metal resistance (Zhang et al., 2013

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Why it matters: Monitoring helps connect symptom changes with lab response and safe refill planning