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Clinical implications of preserved lean mass include maintenance of metabolic rate, physical function, and strength during weight loss

Theofilis P, Sagris M, Oikonomou E, Antonopoulos AS, Siasos G, Tsioufis K, Tousoulis D

This led Pfizer to focus on the development of a once-daily version of the drug, which showed early success in Phase I trials (NCT06567327 and NCT06568731)

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People with obesity frequently exhibit 40-50% lower peak GLP-1 levels and blunted L-cell responsiveness, creating a biological disadvantage that pharmaceutical supplementation can effectively correct