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In this method, a drug is considered to be useful if it can potentially reverse the disease-induced gene expression dysregulation [1, 12]

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66 This phenomenon observed in preclinical studies along with other positive outcomes during the phase I trial have allowed BI836845 to continue to clinical trial phase II, where it is used in combination with an mTOR inhibitor (everolimus) and an aromatase inhibitor (exemestane) in metastatic breast cancer patients (NCT02123823)

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Usage Recommendations: Comes in sterile 1ml ampoules for controlled application