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Oral semaglutide (Rybelsus) requires specific administration instructions: it must be taken on an empty stomach before the first food, beverage, or other oral medications of the day, with no more than 4 ounces of plain water, and patients must wait at least 30 minutes before eating, drinking, or taking other medications

Gastrointestinal side effects are generally dose-dependent with semaglutide

Maintaining open communication with your healthcare provider to ensure safe use of all drugs is essential

This concern comes from early research

At a follow up appointment 3 weeks after discontinuing semaglutide, the patient had not experienced any new lesions and old lesions were in the process of healing.