As Cl ions can directly inhibit this enzyme (Meijer et al., 1992) as well as glucose-6-phosphatase (Pederson et al., 1998) one would expect that changes in [Cl ] i may inversely correlate with glycogen biosynthesis or glucose production
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Alghamdi M, Bashiri FA, Abdelhakim M, Adly N, Jamjoom DZ, Sumaily KM, et al
Mechanism and Side Effects of IGF-1 LR3 Aug 12022 IGF-1 LR3 is a synthetic protein and lengthened analogue of human insulin-like growth factor 1 (IGF-1).It differs from native IGF-1 in that it possesses an arginine instead of a glutamic acid at the third position in its amino acid sequence ("arginine 3"), and also has an additional 13 amino acids at its N-terminus (MFPAMPLLSLFVN) ("long"), for a total of 83 amino acids (relative to the 70 of IGF-1).The consequences of these modifications are that IGF-1 LR3 retains the pharmacological activity of IGF-1 as an agonist of the IGF-1 receptor, has very low affinity for the insulin-like growth factor-binding proteins (IGFBPs), and has improved metabolic stability
Doing so could lead to an increased risk of gastrointestinal side effects without proven benefits
