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Mechanistically, PCK2-K100la augments its kinase activity and competitively inhibits the Parkin-mediated polyubiquitination of 3-oxoacyl-ACP synthase (OXSM), thereby altering mitochondrial fatty acid synthesis and boosting oxidative phosphorylation and the TCA cycle

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Binge drinking means drinking a large amount of alcohol in a short period of time, resulting in a blood alcohol concentration (BAC) level of 0.08% or higher

In these settings, scientists analyze how signaling pathways support vascular coordination and adaptive regulation

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