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Per cigarette level of normalized total PAHs, total NNAL, cotinine and trans-3-hydroxycotinine were estimated by dividing the concentrations by the number of cigarettes the subject reported smoking per day

Reported trial findings were mixed

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710,13 In a systematic literature review, young e-cigarette users endorsed them as a safer option than combustible cigarettes and viewed them as an effective cessation aid

The authors also identified evidence for worse stress response among OC users, regardless of smoking status, compared to non-OC users