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"Increasing the nicotine dose from 1 to 2 mg did not increase the thermogenic effect but produced side effects in most subjects." "If the thermogenic effect of adding caffeine can be translated into a corresponding enhancement of nicotine's effect on long-term energy balance, it may be useful in the prevention of weight gain after smoking cessation." In 2005 the same researchers demonstrated that the chewing gum tested also reduced the appetite of slim subjects