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Instead of relying on external substances to feel interesting or confident, it is important to focus on developing genuine interests, talents, and skills that can be shared with others in a positive and meaningful way.

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The fact that i) these 8 patients were diagnosed years ago [12], ii) none of them originally experienced major vascular events (1 individual with the COL1A1 variant showed aortic ectasia, uncomplicated tortuous vertebral arteries, and left ventricular thickening), and iii) all underwent periodical vascular surveillance that resulted negative at the time of writing, suggests that the supposed genotype-phenotype correlations of these variants should not be considered valid in all cases

But its boring and dirty like 80% of the time

That isnt surprising