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Among the substances commonly used in vaping, nicotine is the most problematic

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Sci Rep 7(1):13825 Polosa R, Casale TB, Tashkin DP (2022) A close look at vaping in adolescents and young adults in the United States

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Cell Signaling Pathways Affected by NNK and Cigarette Smoke Extract Similarly to the effect of nicotine on the Akt pathway, up-regulation of the Akt kinase phosphorylation/activation was shown to be induced by NNK and cigarette smoke extracts (CSE) in pancreatic ductal cells