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FDA-approved medications for tobacco cessation are intended to help individuals quit smoking by either: Making the effects of nicotine less pleasurable Reducing the negative side-effects of nicotine withdrawal, which may include depression, insomnia, irritability, anxiety, or weight gain

High-pH adjusters used to facilitate nicotine absorption activate TRPV1 nerve receptors, creating a sensation of heat or stinging

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If smoking helps keep you on an even keel throughout the day, that can become a problem after you quit. The Effect of Nicotine on Your ZZZs Heres how nicotine affects your sleep both while youre still smoking and in the weeks after you quit