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Maki Inoue-Choi, PhD, MS , staff scientist in the metabolic epidemiology branch of the division of cancer epidemiology and genetics at the National Cancer Institute, and colleagues wrote that despite studies indicating that nondaily smoking is associated with elevated mortality, there is a common perception among smokers that nondaily smoking poses little or no harm. Inoue-Choi and colleagues assessed the risk for all-cause and cause-specific mortality among daily smokers and nondaily smokers based on the number of cigarettes they smoke every month and years since they lowered their consumption from daily smoking or quit smoking

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This is due to the increased activity of the sympathetic nervous system, which is responsible for the "fight or flight" response