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How and when to take antacids Check the instructions on the packet or leaflet to see how much antacid to take and how often

This means that small amounts of nicotine may enhance performance, but higher doses or long-term use can lead to impairment

The government says it wants to introduce the changes in phases to lessen the economic shock on retailers and give people with mental health issues - a group with far higher smoking rates - time to manage the change.

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SUs are mainly metabolised hepatically, in particular by CYP2C9 and to a lesser extent by CYP3A4, whereas gliclazide is substrate for CYP2C19