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Denatured tirzepatide is less effective or completely inactive
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appropriate doseresponse controls are recommended
61 In practice, some patients may be able to switch to very high dose (ie, 2000 mcg daily) oral supplementation instead of continuing parenteral administration, but it is impossible to predict in whom this can be done safely, and many are at risk of worsening symptoms which may become permanent
Ethical Practices: Ensuring patient consent, maintaining confidentiality, and practising within scope
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