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We use a Burden of Proof meta-analysis to generate conservative risk estimates and find weak-to-moderate evidence that tobacco chewers have an increased risk of stroke, lip and oral cavity cancer, esophageal cancer, nasopharynx cancer, other pharynx cancer, and laryngeal cancer

Issues in Mental Health Nursing, 45 (5)

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doi:10.1371/journal.pone.0227837

A sore that bleeds easily and doesn't heal A lump or thickening anywhere in your mouth or neck Soreness or swelling that doesn't go away A red or white patch that doesn't go away A red or white patch that doesn't go away Even if you don't find a problem today, see your doctor or dentist every three months to have your mouth checked