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They have been marketed as less harmful alternatives to cigarettes, [81] but very few are as yet approved as NRTs in any jurisdiction

Diagnostic and Statistical Manual of Mental Disorders , 4th edn

He led the airline into an overall efficient profitable flying machine. While the major carriers remained tethered to hub and spoke method of service, meaning a central airport from which flights emanated, Southwest instead flew to both large metropolitan cities as well as underserved cities using direct flights and often bypassing larger airports

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Some major league players have not welcomed these reforms