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Some studies have shown that the concentration of nicotine in stomach acid is greater than that in the blood stream and its believed this could play a role in increased production of acid in your stomach

Psychopharmacology (Berl) 90 : 101105

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it is a manifestation of some inflammatory process that could be rheumatoid arthritis, infections, or something else, says Alexa Meara, MD, a rheumatologist at The Ohio State University Wexner Medical Center in Columbus, Ohio